rigininchinacannotbesuortedbyychromosomeevidence.
chinahasaneecialstrongadvantageinpolygenicdiseaseresearchasnumerouspopulatioandabundantgeneticresource.thereisattachingmuchimportancetoimpactofpopulationgeneticstructureinchinauponpolygenicdiseaseresearch.eentialhyperteionhasbeenpaidmuchattentioninthestudyofdiseasesusceptibilitygenes,whileeentialhypoteionremaileaststudied,becauseofitsextremelylowmorbidity.inourresearch,weusehypoteionpedigreetostudythebloodregulationgenes,whichrelatedwithraassystem,andinthelongrun,theresultsmaygivesomeindicatioforhyperteionsusceptibilitygenes.cancerhasbeenaharmfulandcomplexdisease,whichisresultedfromtheinteractionamongmultiplefactors.nasopharyngealcarcinoma,cisakindmalignanttumorinchinesepopulatio,eeciallyinsouthernprovincessuchasguangdong,guangxi,hunanandfujianetc.wecollectedtenpedigreesamplesfromwutong,guangxi,andinanattempttoidentifysusceptibilitylocifornasopharyngealcarcinoma(c)andtheeentialhypoteion.wholegenomescanwasemployedtostudyfamiliarcandhypoteionsamples.linkageanalysisusinggenehunterprogramshowssomeinterestinglocion2,6,9chromosomes,amongthem,d6s422markerlodscore(zall)=1.198874,l=2.33113(p=0.00684)withmostsuggestivelinkagetocsusceptibility.inthestudyofhypoteion,someregioon2,7,11chromosomepresentsignificantlinkage,d2s112,lodscore(zall)=1.312986,l=2.25152(p=0.00799),d11s901lodscore(zall)=2.089601,l=2.37206(p=0.00576).someofresultsweresuortedformthepreviousdata.thesechromosomeregiowillprovi
desomevaluablecandidategeneforres